The Lords fall down

Atishoo! Atishoo! we all fall down!

We report the unusual case of an elderly lady with glaucoma and sneeze syncope because of transient complete atrioventricular block, who had resolution of syncopal and pre-syncopal symptoms following removal of her beta-blocker eyedrops. This case suggests a previously unrecognised pathophysiology in sneeze syncope and illustrates the potential problems associated with the systemic absorption o...

Ola: What Goes Up, Must Fall Down

We have made a robot soccer model using LEGO Mindstorms robots, which was shown at RoboCup98 during the World Cup in soccer in France 1998. For the robot soccer model, we constructed a stadium out of LEGO pieces, including stadium light, rolling commercials, moving cameras projecting images to big screens, scoreboard and approximately 1500 small LEGO spectators who made the “Mexican wave” as kn...

BH3-only proteins: the lords of death.

Although the mechanisms by which Bcl-2 family proteins control the apoptotic machinery of the cell are not fully understood, it becomes clear that the role of BH3-only proteins consists in serving as sensors or sentinels of cellular damage, transducing the apoptotic stimuli to the mitochondria. For this reason, mammalian cells have developed several strategies for their strict regulation throug...

AAA Proteins: Lords of the Ring

AAA ATPases (those associated with various cellular activities) 1 play important roles in numerous cellular activities including proteolysis, protein folding, membrane trafficking, cytoskeletal regulation, organelle biogenesis, DNA replication, and intracellular motility. Recent structural and enzymatic studies are providing clues into the properties of the conserved AAA domain that defines thi...

Debate in the House of Lords